After nearly 50 years in the Greater Los Angeles Area, including 15 seasons at Anaheim Stadium, owner Georgia Frontiere announced that the team would relocate to St. Louis, Missouri on January 15, 1995.

While the owners initially rejected the move, permission was eventually granted therefore bringing an end to Southern California's first major professional sports franchise until 2016.

[1] The threat of relocation dominated talk about the Rams from early in the offseason right up to the moment the move was announced and it had a major effect on the franchise's standing in the market.

Leigh Steinberg organized a group known as "Save the Rams" and attempted to reach out to ownership and strike a deal to keep the team in the Southern California market, however, their efforts proved to be unsuccessful.

At the end of the season, head coach Chuck Knox was fired after three consecutive last place finishes in the NFC West and Frontiere also relieved John Shaw of his General Manager duties, although he remained with the team as a high-ranking executive.

Due to later rule changes that declare a punted ball dead when it hits the ground in the end zone, this play is currently unable to be replicated in the NFL.

Los Angeles was able to take the lead in the fourth quarter on a 22-yard pass play by Chris Miller, but the 49ers responded with a touchdown drive of their own to take a 31–27 advantage.

The Rams jumped out to a 14–6 lead in the first half, but Los Angeles was unable to hold off the eventual AFC Champion Chargers and fell 31–17.

In front of a sparse crowd of around 34,000 at Tampa Stadium, Los Angeles dropped its fifth game in a row and in the process became mathematically eliminated from playoff contention for the fifth consecutive season.

In front of the smallest crowd at Anaheim Stadium, the Rams closed out their tenure in Southern California with a loss to the 2–13 Washington Redskins.

On March 15, 1994, the National Football League owners rejected Ms. Frontiere's bid to move the franchise to St. Louis, Missouri, her native city, by a 21–3–6 vote, with the Raiders abstaining.

The commissioner also added:"Once the bridges have been burned and people get turned off on a sports franchise, years of loyalty is not respected and it is difficult to get it back.

"[6][7] Frontiere, however, responded with a thinly veiled threat at a lawsuit and the NFL owners eventually acquiesced to her demands, weary of going through a long, protracted legal battle.