Andre Agassi defeated defending champion Pete Sampras in the final, 4–6, 6–1, 7–6(8–6), 6–4 to win the men's singles tennis title at the 1995 Australian Open.

A memorable moment occurred in the quarterfinal match between Sampras and Jim Courier.

Shortly after winning the first game of the fifth set, Sampras was overcome with grief over his then-coach, Tim Gullikson.

(Gullikson had suffered several seizures while touring with Sampras in Europe in late 1994.

Shortly before Sampras' match against Courier, Gullikson had collapsed during a practice session after suffering another seizure, with tests proving inconclusive at Epworth Hospital and being flown home to Chicago for further tests.)