The 1995 Tyson Holly Farms 400 was the 27th stock car race of the 1995 NASCAR Winston Cup Series and the 46th iteration of the event.

After a 36-race absence, the race marked the NASCAR Winston Cup Series return for Ernie Irvan, who had suffered major head and lung injuries in a practice session at the 1994 GM Goodwrench Dealer 400.

It measures 0.625 mi (1.006 km) and features a unique uphill backstretch and downhill frontstretch.

The speedway briefly reopened in 2010 and hosted several stock car series races before closing again in the spring of 2011.

Ted Musgrave, driving for Roush Racing, would win the pole, setting a time of 19.004 and an average speed of 118.396 miles per hour (190.540 km/h) in the first round.