Incumbent Senator Ben Nighthorse Campbell won re-election to a second term by a landslide.

This was Campbell's first election as a Republican as he left the Democratic Party in 1995.

As of 2024, this is the last time that a Republican won the Class 3 Senate seat from Colorado, and the last time that a Native American was elected to the United States Senate until 2022.

Campbell, who was elected in 1992 as a Democrat, switched parties after the 1994 Republican Revolution.

[2][3] In fact, throughout the entire campaign, Lamm mostly sent out negative attack advertisements about Campbell.