The 1999–2000 Busta Cup was the 34th edition of what is now the Regional Four Day Competition, the domestic first-class cricket competition for the countries of the West Indies Cricket Board (WICB).

Barbados topped the table after the round-robin,[1] but lost to the Leeward Islands in their semi-final.

However, the Leeward Islands lost to Jamaica in the final, who won their fifth domestic first-class title.

Jamaica's Chris Gayle was the leading run-scorer and was named player of the tournament, while Curtly Ambrose of the Leeward Islands and Guyana's Mahendra Nagamootoo were the equal leading wicket-takers.

The top five run-scorers are included in this table, listed by runs scored and then by batting average.