1999–2000 Campionato Sammarinese di Calcio

The 1999–2000 Campionato Sammarinese di Calcio season was the 15th season since its establishment.

It was contested by 16 teams, and S.S. Folgore/Falciano won the championship.

All teams play twice against the teams within their own group and once against the teams from the other group.