The 1999–2000 Cupa României was the 62nd edition of Romania's most prestigious football cup competition.
The title was won by Dinamo București against FC U Craiova.
First round proper matches are played on the ground of the lowest ranked team, then from the second round proper the matches are played on a neutral location.
If a match is drawn after 90 minutes, the game goes into extra time.
From the first edition, the teams from Divizia A entered in competition in sixteen finals, rule which remained till today.