The 1999–2000 Divizia C was the 44th season of Liga III, the third tier of the Romanian football league system.
Subsequently was renamed as Pro Mobila Vatra Dornei.
Unirea Botoșani merged with Fortus Iași, the first one being absorbed by the second one.
Petrolul Roata de Jos ceded its place to Atletic București.
Minerul Mătăsari, and Metalurgistul Cugir were spared from relegation.