The 1999–2000 season are the Esteghlal Football Club's 8th season in the Azadegan League, and their 6th consecutive season in the top division of Iranian football.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Updated to match played 13 October 2018Source: Competitions

Source: RSSSF Win Draw Loss Postponed