were defending their title, having won the 1998–99 Omani League season.
Al-Oruba SC emerged as the champions of the 1999–2000 Omani League with a total of 42 points.
This season the league had 10 teams.
Oman Club and Al-Ittihad Club were relegated to the Second Division League after finishing in the relegation zone in the 1998–99 season.
The relegated teams were replaced by Second Division League teams Ruwi Club and Bawshar Club.