The 1999–2000 Saint Louis Billikens men's basketball team represented Saint Louis University in the 1999–2000 NCAA Division I men's basketball season.

The Billikens were led by head coach Lorenzo Romar who was in his first season at Saint Louis.

The team played their home games at Scottrade Center.

They won the C-USA tournament to receive an automatic bid to the NCAA tournament where they were defeated by Utah in the opening round.

Guard Justin Love (18.2) and forward Justin Tatum (8.3) led the team in scoring.