The 1999 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as an independent during the 1999 NCAA Division I-AA football season.
Led by third-year head coach Larry Welsh, Cal Poly compiled a record of 3–8 for the second consecutive year.
[1] The team was outscored by its opponents 345 to 246 for the season.
The Mustangs played home games at Mustang Stadium in San Luis Obispo, California.. [12]