The 1999 Michigan State Spartans football team represented Michigan State University in the 1999 NCAA Division I-A football season.

During the bowl game, the Spartans were coached by interim head coach Bobby Williams, who led the Spartans to a 37–34 victory in the 2000 Florida Citrus Bowl over the Florida Gators of the Southeastern Conference, with a last second, game-winning field goal by kicker Paul Edinger.

This Spartan team featured the likes of Plaxico Burress, T. J. Duckett, Julian Peterson, and Renaldo Hill, and goes down as one of the best Spartan teams in the BCS era.

Burke broke Ed Smith's record of 369 against Indiana in 1979 while Burress surpassed Andre Rison's 252 yards against Georgia in 1989.

Michigan State was now 6–0 for the first time since the 1966 national championship season.