The 1999 TSFL season was the 115th season of the Tasmanian State Football League (TSFL), the highest-level senior Australian rules football competition in Tasmania.

From this season the competition would be under the control of a new independent governing body of the sport in Tasmania named Football Tasmania as part of recommendations set down by the Australian Football League's Biggs Report investigation into the strong decline in interest and financial disarray of the TFL competition.

From this season North Hobart were rebranded as the Hobart Demons under a marketing arrangement with their major sponsor Harris Scarfe (formerly FitzGerald's) whilst New Norfolk were rebranded as the Derwent Eagles to reflect their entire region (Derwent Valley).

On 31 May, Southern Districts folded after just eighteen months due to ongoing financial difficulties and falling support whilst Derwent Eagles (New Norfolk) were excluded from the competition after this season for both financial and geographical reasons, they were paid a sum of money to leave the TSFL by Football Tasmania and joined the SFL the following season.

(Friday, 20 August & Saturday, 21 August 1999) Note: The New Norfolk/Derwent Eagles' final TFL match and the final TFL match at Boyer Oval.