The 1999 Western Illinois Leathernecks football team represented Western Illinois University as a member of the Gateway Football Conference during the 1999 NCAA Division I-AA football season.
They were led by first-year head coach Don Patterson and played their home games at Hanson Field in Macomb, Illinois.
The Leathernecks finished the season with a 7–4 record overall and a 2–4 record in conference play.
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