The 2000–01 Cupa României was the 63rd edition of Romania's most prestigious football cup competition.
First round proper matches are played on the ground of the lowest ranked team, then from the second round proper the matches are played on a neutral location.
If a match is drawn after 90 minutes, the game goes into extra time, where it works golden goal rule.
If the match is still tied, the result is decided by penalty kicks.
From the first edition, the teams from Divizia A entered in competition in sixteen finals, rule which remained till today.