The 2000–01 Israeli Premier League season had Maccabi Haifa win the title, while Bnei Yehuda and Tzafririm Holon were relegated.
The table was then divided into two groups, the upper and lower, which had six teams each.
One team from Liga Leumit was promoted at the end of the previous season: Hapoel Tzafririm Holon.
The three teams relegated were: Hapoel Kfar Saba, Maccabi Herzliya and Hapoel Jerusalem.
First 6 teams played in the top playoffs while the last 6 teams played in the bottom playoffs.