The 2000–01 NSW Premier League season was the inaugural season of the NSW Premier League.
The competition replaced the NSW Super League as the top-tier competition in New South Wales.
The second-tier competition became the NSW Winter Super League.
The competition began on Friday, 3 November 2000 at St George Stadium for the Round 1 fixture between St George Saints and Canterbury-Marrickville.
The competition concluded with the grand final being played on Sunday, 8 April 2001 at Marconi Stadium, with Bonnyrigg White Eagles FC taking out the title by defeating Premiers Blacktown City FC 3–1.