As many as 231 goals were scored in the 90 matches played in this edition of the league.
Al-Oruba SC were defending the title they had won in the 1999–00 Omani League season.
emerged as the champions of the 2000–01 Omani League with a total of 41 points.
Sohar SC and Fanja SC were relegated to the Second Division League after finishing in the relegation zone in the 1999-00 season.
The two relegated teams were replaced by Second Division League teams Oman Club and Al-Ahli Club.