Boavista won their first league title, becoming only the second champions from outside the Portuguese "Big Three" (Os Três Grandes) of Benfica, Porto and Sporting, after Belenenses in the 1945–46 season.
At the bottom of the table, Campomaiorense, Desportivo das Aves and Estrela da Amadora were relegated to the Segunda Liga.
This season saw also Benfica finish sixth, their lowest ever Primeira Liga position.
Vitória de Setúbal, Rio Ave and Santa Clara were consigned to the Segunda Liga after finishing as the bottom three teams in 1999–2000 season.
The other three teams were replaced by Paços de Ferreira, Beira-Mar and Desportivo das Aves from the Segunda Liga.