The 2000–01 St. Francis Terriers men's basketball team represented St. Francis College during the 2000–01 NCAA Division I men's basketball season.

The team was coached by Ron Ganulin, who was in his tenth year at the helm of the St. Francis Terriers.

The Terriers' home games were played at the Generoso Pope Athletic Complex.

The Terriers finished the season at 18–11 overall and 16–4 in conference play, to win their first Conference Regular Season Championship since being members of the NEC.

The Terriers received a bye in the first round of the 2001 NEC Tournament and proceeded to defeat Wagner in the semifinals.