The 2000–01 USC Trojans men's basketball team represented the University of Southern California during the 2000–01 NCAA Division I men's basketball season.

Led by head coach Henry Bibby, they played their home games at the L. A.

Sports Arena in Los Angeles, California as members of the Pac-10 Conference.

The Trojans finished the season with a record of 24–10 (11–7 Pac-10) and made a run to the Elite Eight of the NCAA tournament.

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