The 2000–01 West Midlands (Regional) League season was the 101st in the history of the West Midlands (Regional) League, an English association football competition for semi-professional and amateur teams based in the West Midlands county, Shropshire, Herefordshire, Worcestershire and southern Staffordshire.
The Premier Division featured 20 clubs which competed in the division last season, along with three new clubs: Also, Smethwick Rangers changed name to Warley Rangers.