Colin Lee began the season as manager but was sacked in December 2000 with the team just a single point clear of the relegation zone.
[1] Former Southampton manager Dave Jones replaced him in early January but could not take the side any higher than mid-table.
[2] Wolves' pre season saw them travel to Ireland to play three local sides.
They then returned home to play three Premiership teams at Molineux; the fixture against Aston Villa was a testimonial match for Mike Stowell.
The provisional fixture list was released on 22 June 2000, but was subject to change in the event of matches being selected for television coverage or police concerns.