Andre Agassi defeated defending champion Yevgeny Kafelnikov in the final, 3–6, 6–3, 6–2, 6–4 to win the men's singles tennis title at the 2000 Australian Open.

With the win, Agassi became the reigning champion at three of the four majors, missing only the 1999 Wimbledon Championships.

This was the first Australian Open for future six-time champion and world No.

1 Roger Federer, and marked his first match win at a major.

This tournament marked the final major appearance of former world No.