The Red Sox finished second in the American League East with a record of 85 wins and 77 losses, 2+1⁄2 games behind the New York Yankees, who went on to win the 2000 World Series.

The Red Sox did not qualify for the postseason, as the AL wild card went to the Seattle Mariners, who had finished second in the American League West with a record of 91–71.

Infielders Other batters Coaches Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.

= Batting average; HR = Home runs; RBI = Runs batted in; SB = Stolen bases Note: G = Games pitched; GS = Games started; IP = Innings pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts Note: G = Games pitched; GS = Games started; IP = Innings pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average In addition to the DSL Red Sox, the team shared a DSL team with the Arizona Diamondbacks.

VSL cooperative was with the Milwaukee Brewers and Minnesota Twins.