The 2000 Copa Mercosur was the 3rd season of the Copa Mercosur, CONMEBOL's club tournament for countries in the southern part of the continent.

The competition started on 1 August 2000 and concluded on 20 December 2000 with Vasco da Gama beating Palmeiras in the final for its first title.

1–1 on aggregate, Vasco da Gama won 5–4 on penalties.

Atlético Mineiro won 4–2 on aggregate.

Vasco da Gama won 5–1 on aggregate.