The 2000 Critérium du Dauphiné Libéré was the 52nd edition of the cycle race and was held from 4 June to 11 June 2000.

The race started in Grenoble and finished in Sallanches.

The race was won by Tyler Hamilton of the U.S.

Postal Service team.

Fourteen teams, containing a total of 112 riders, participated in the race:[2]