In their sixth year under head coach Lloyd Carr, the Wolverines compiled a 9–3 record (6–2 in conference games), outscored opponents by a total of 373 to 201, and finished in a three-way tie for the Big Ten championship.

Five Michigan players received first-team honors on the 2000 All-Big Ten Conference football team: Thomas (Coaches-1, Media-1); Terrell (Coaches-1, Media-1); Hutchinson (Coaches-1, Media-1); tackle Jeff Backus (Coaches-1, Media-1); and linebacker Larry Foote (Coaches-1, Media-2).

[16] Anthony Thomas set several school records: single-season carries (319), eclipsing the 303 mark by Tim Biakabutuka set five years earlier and broken three years later by Chris Perry; career carries (924), breaking Jamie Morris' thirteen-year-old record of 809 and broken seven years later by Mike Hart; career yards (4472), also breaking Jamie Morris' thirteen-year-old record of 4393 and broken seven years later by Hart; career rushing touchdowns (52), breaking Tyrone Wheatley's six-year-old record of 47 and still standing;[17] single season yards per game (144.4), eclipsing Morris' 141.9 from 1987 and still standing; single-season 150-yard games (6), surpassing Morris and Rob Lytle who had 5 in 1987 and 1976, respectively; career 100-yard games (22) eclipsing Wheatley's 20 in 1994 and surpassed by Hart in 2007; career 150-yard games (9), surpassing Morris' 7 set in 1987 and surpassed by Hart in 2007.

[18] Drew Henson ended his career with the current school record for lowest interception percentage (1.87), surpassing Michael Taylor's 2.55 set in 1989.

[20] Roster The individuals in the sections below earned recognition for meritorious performances at the national, conference and team levels.