The team was coached by Frank Solich and played their home games in Memorial Stadium in Lincoln, Nebraska.

The Cornhusker's 2000 Red-White spring game featured Nebraska's first (and currently only) female player: KaLena "Beanie" Barnes, a senior sprinter for Nebraska's women's track-and-field teams, played in spring practice as a punter and recorded one 35-yard punt.

The season was concluded by #9 Nebraska blowing out #18 Northwestern by 66–17, the largest margin of victory in Alamo Bowl history.

Head Coach Frank Solich's career record improved to 31–7 (18–6).

[5] The following Nebraska players who participated in the 2000 season later moved on to the next level and joined a professional or semi-pro team as draftees or free agents.