Democratic Mike Stack defeated incumbent Republican Frank A. Salvatore in the 5th senatorial district.

Republican Donald C. White defeated the democratic nominee to succeed the retiring Patrick J. Stapleton, Jr. in the 41st senatorial district.

Democratic Sean Logan succeeded the retiring Albert V. Belan.

Republican Bill Slocum remained on the ballot in the 25th senatorial district, even after his resignation from the senate on June 1, 2000.

Slocum pleaded guilty and spent a month in federal prison for filing false reports to the Pennsylvania Department of Environmental Protection and discharging raw sewage into Brokenstraw Creek while he was a sewage plant manager in Youngsville, Pennsylvania.