The 84th running of the Tour of Flanders cycling race in Belgium was held on Sunday 2 April 2000.

Naturalized Belgian Andrei Tchmil won the monument classic ahead of Dario Pieri and Romāns Vainšteins.

Defending champion Peter Van Petegem attacked on Tenbosse, but to no effect.

Johan Museeuw tried to go clear on the Muur van Geraardsbergen, but was caught by a large group before the top.

After the Bosberg, 11 km from the finish, Andrei Tchmil attacked on a flat stretch and powered on to Meerbeke.