Democrats defeated incumbent Republicans in Delaware, Michigan, Minnesota, Missouri, and Washington, and they won an open Republican-held seat in Florida.

Additionally, Republican Senator Paul Coverdell of Georgia died earlier in the year and was replaced by Democratic appointee Zell Miller, who then went on to win the special election.

John Chafee of Rhode Island had previously announced his intent to retire at the end of his term, however, he died in office on October 24, 1999.

Primary election results: Despite touting his service as a moderate Republican representing a strongly Democratic district, Campbell was underfunded and a decided underdog against the popular, heavily financed Feinstein.

However, Roth received more votes than Presidential candidate George W. Bush, suggesting the strength of the Democratic turnout was a boon to Carper's candidacy and a key element of his victory.

[22] The Republican fought back by connecting him to liberal Democrat Ted Kennedy of Massachusetts, and on his vote to block legislation aimed at protecting Social Security.

Miller conceded he would vote for Gore because he helped him when he was governor including drought relief, welfare reform, and the Atlanta Olympics.

The election was notable for a strong third-party performance from Libertarian Carla Howell, who finished less than a percent behind Republican Jack E. Robinson.

Stabenow also performed well in other heavily populated areas such as Ingham County home to the state's capital of Lansing, and the college town of Ann Arbor.

Abraham did not concede right after major news networks declared Stabenow the winner; He held out hope that the few outstanding precincts could push him over the edge.

In the general election for the state's seat in the U.S. Senate, Ashcroft was facing then-Governor Mel Carnahan in a "tight" race, despite the senator having a larger budget than Carnahan, a war chest that included significant contributions from corporations such as Monsanto Company,[39] headquartered in St. Louis, Missouri, which gave five times more to Ashcroft's campaign fund than to the fund of any other congressional hopeful at the time.

[41] The voters of Missouri, by a margin of approximately fifty thousand votes,[42] chose for the U.S. Senate Mel Carnahan, their Governor who had died two weeks before the election.

No one had ever posthumously won election to the Senate, though voters on at least three other occasions had until then chosen deceased candidates for the House of Representatives: Clement Woodnutt Miller (D) in California in 1962; Nick Begich (D) in Alaska, 1972; and Hale Boggs (D) in Louisiana, 1972.

Though Sam Rankin won the Reform Party's nomination for the United States Senate, he dropped out of the race over the summer and was replaced by Gary Lee.

[49] Schweitzer primarily challenged Burns on the issue of prescription drugs, organizing busloads of senior citizens to take trips to Canada and Mexico for cheaper medicine.

Democrat Ben Nelson won the open seat, beating Don Stenberg, the Republican Attorney General of Nebraska.

Franks, a moderate Republican,[58] attacked Corzine for "trying to buy the election and of advocating big-government spending programs that the nation can ill afford."

Corzine accused Franks of wanting to dismantle the Social Security system because he supported Governor George W. Bush's partial privatization plan.

[70] Despite being heavily outspent, Franks lost by only three percentage points, doing better that year than Republican Governor George W. Bush in the presidential election, who obtained just 40% of the vote in the state.

In late April and May 2000, Giuliani's medical, romantic, marital, and political lives all collided in a tumultuous four-week period, culminating in his withdrawing from the race on May 19.

Her plan included specific tax credits with the purpose of rewarding job creation and encouraging business investment, especially in the high-tech sector.

The major issue there was the persistently weak local economy, which Lazio hoped to link to his opponent's husband's tenure in office.

[83] Talk radio hammered on this, with New York-based Sean Hannity issuing a daily mantra, "Name me three things Hillary Clinton has ever done for the people of New York!"

Clinton's supporters pointed out that the state was receptive to national leaders, such as Robert F. Kennedy who was elected to the Senate in 1964 despite similar accusations.

This issue caused former New York Mayor Ed Koch to take out ads telling Lazio to "stop with the sleaze already,"[90] and did not change the dynamic of the race.

[93][94] Clinton won the traditionally Democratic base of New York City by large margins, and carried suburban Westchester County, but lost heavily populated Long Island, part of which Lazio represented in Congress.

[100] Santorum had gained a reputation as a polarizing figure during his first term in the Senate, but he entered the race with a large fundraising advantage and high levels of support from the political right.

Congressman Klink narrowly bested State senator Allyson Schwartz and former Lieutenant Governor nominee Tom Foley by running on the message that he was the only candidate capable of defeating the Republican.

Santorum, in contrast, successfully balanced his national recognition on social issues with local concerns en route to a surprisingly large victory.

In a field of five candidates, Jeff Clark, a professor at Middle Tennessee State University, edged out John Jay Hooker to win the nomination.