The 2001 African Cup Winners' Cup was the twenty-seventh season of Africa's second oldest club football tournament organised by CAF.

For Kaizer Chiefs the year 2001 included the highs of being crowned African Club of the Year and lifting the African Cup Winners' Cup, but it also included the lows of the Ellis Park Stadium disaster in which 43 South African football fans lost their lives.

A total of 37 teams from 36 CAF associations qualified for the tournament after winning their respective premier domestic cups.

The away goals rule was used to determine the victors in the event of a match being tied over the two-legs.

Kaizer Chiefs won the two-legged final 2–1 on aggregate.