The 2001 All-Ireland Under-21 Hurling Championship was the 38th staging of the All-Ireland Under-21 Hurling Championship, the Gaelic Athletic Association's premier inter-county hurling tournament for players under the age of twenty-one.

The championship began on 6 June 2001 and ended on 16 September 2001.

Limerick were the defending champions.

[1] On 16 September 2001, Limerick won the championship following a 0-17 to 2-10 defeat of Wexford in the All-Ireland final.

Limerick's Mark Keane was the championship's top scorer with 3-29.