The 2001 Campionati Internazionali di Sicilia was a men's tennis tournament played on outdoor clay courts in Palermo, Italy that was part of the International Series of the 2001 ATP Tour.

It was the 23rd edition of the tournament and ran from 24 September until 30 September 2001.

Unseeded Félix Mantilla won the singles title.

Félix Mantilla defeated David Nalbandian 7–6(7–2), 6–4 Tomás Carbonell / Daniel Orsanic defeated Enzo Artoni / Emilio Benfele Álvarez 6–2, 2–6, 6–2