The 2001 Canisius Golden Griffins football team represented Canisius College represented Canisius College as a member of the Metro Atlantic Athletic Conference (MAAC) during the 2001 NCAA Division I-AA football season.
Led by second-year head coach Ed Argast, the Golden Griffins compiled an overall record of 1–9 with a mark of 1–6 in conference play, tying for seventh place at the bottom of the MAAC standings.
[1] The Canisius offense scored 175 points while the defense allowed 404 points.