The 2001 Coca-Cola 600, the 42nd running of the event, was a NASCAR Winston Cup Series race held on May 27, 2001, at Lowe's Motor Speedway in Charlotte, North Carolina.

Contested at 400 laps on the 1.5 mile (2.4 km) speedway, it was the twelfth race of the 2001 NASCAR Winston Cup Series season.

The complex features a 1.5 miles (2.4 km) quad oval track that hosts NASCAR racing including the prestigious Coca-Cola 600 on Memorial Day weekend and The Winston, as well as the UAW-GM Quality 500.

The speedway was built in 1959 by Bruton Smith and is considered the home track for NASCAR with many race teams located in the Charlotte area.

Tony Stewart successfully performed the "Double Duty", also running the Indianapolis 500 the same day; Joe Gibbs Racing had Mike McLaughlin on standby if he did not arrive on time.