The Copa Merconorte 2001 was the fourth and final edition of association football tournament Copa Merconorte held in 2001.

Millonarios of Colombia defeated Emelec of Ecuador in the final.

[1] It was the first edition to include teams invited from the United States, the Kansas City Wizards and NY/NJ MetroStars.

Several fixtures for the MetroStars were cancelled following the September 11 attacks.

Both series were decided in penalty kicks because the net of both games was a draw.