The 2003–04 UEFA Cup first round was played from 24 September to 16 October 2003.
[1] All times are CEST (UTC+2), as listed by UEFA.
The draw was held on 29 August 2003, 13:00 CEST, at the Grimaldi Forum in Monaco.
Teams were divided into geographical groups, each with seeded and unseeded pots.
[2] The first round featured the 41 winners of the qualifying round, joined by 36 directly qualified teams, the 16 losers of the Champions League third qualifying round and the 3 winners for the Intertoto Cup.
Levski Sofia won 5–0 on aggregate.
2–2 on aggregate; Torpedo Moscow won 3–2 on penalties.
Groclin Grodzisk Wielkopolski won 1–0 on aggregate.
2–2 on aggregate; Wüstenrot Salzburg won on away goals.
1–1 on aggregate; Hajduk Split won on away goals.
Red Star Belgrade won 6–5 on aggregate.