Andre Agassi defeated Rainer Schüttler in the final, 6–2, 6–2, 6–1 to win the men's singles tennis title at the 2003 Australian Open.

Thomas Johansson was the reigning champion, but did not participate due to injury.

Tim Henman and Greg Rusedski's withdrawals from the tournament marked the first time there were no British players competing in the Australian Open in the Open Era.

This event marked the first main-draw major appearance for David Ferrer, who lost to Lee Hyung-taik in the first round; it was also the final major appearance for former world No.

Andre Agassi is the champion; others show the round in which they were eliminated.