Miami started the scoring with quarterback Ben Roethlisberger throwing a 28-yard touchdown pass to wide receiver Michael Larkin to post an early 7–0 lead.
Ben Roethlisberger threw a 12-yard touchdown pass to wide receiver Martin Nance to give Miami a 21–0 first quarter lead.
Early in the second quarter, Lionel Gates scored a rushing touchdown for Louisville to make it 21–7.
Louisville running back Michael Bush threw a 31-yard touchdown pass to wide receiver JR Russell to make it 35–14.
Stefan Lefors threw a 24-yard touchdown pass to Russell in the third quarter, to make the score 35–28 Miami, but Louisville would get no closer.