APOP Kinyras won their 1st title.
Fourteen teams participated in the 2004–05 Cypriot Second Division.
The team with the most points at the end of the season crowned champions.
The first three teams were promoted to 2005–06 Cypriot First Division and the last three teams were relegated to the 2005–06 Cypriot Third Division.
Teams promoted to 2004–05 Cypriot First Division Teams relegated from 2003–04 Cypriot First Division Teams promoted from 2003–04 Cypriot Third Division Teams relegated to 2004–05 Cypriot Third Division