The structure of the competition was a purely knockout format; teams played each other on a home and away basis, with the aggregate points winner proceeding to the next round.

The competition began on 4 December 2004 and culminated in the final at Kassam Stadium in Oxford on 21 May 2005.

Auch secured a victory over Worcester Warriors in the final and picked up their first piece of European Club silverware.

[3] AA Coimbra subsequently declined to play in the competition.

[4] Leeds Tykes Worcester Warriors Auch Bayonne Catania Gran Parma L'Aquila Leonessa Petrarca Padova Rovigo AA Coimbra Valladolid RAC Clube Rugby Lisboa București Bera Bera UC Madrid All kick off times are local.