Under the new sponsor, the two streams, Coastal and Inland, were merged into a single national league.
[2] The champions were Free State Stars, who were promoted to the South African Premier Division.
Tembisa Classic also earned promotion, after winning the playoffs.
[3] Four clubs were relegated, as the following 2005–06 National First Division was reduced from 18 to 16 teams.
Manning Rangers, who finished 15th in the 2004–05 Premier Soccer League, were relegated to the 2005–06 National First Division Tembisa Classic earned promotion to the 2006–07 Premier Soccer League.