In the 2004–05 season Panathinaikos played for 46th consecutive time in Greece's top division, Alpha Ethniki.

They also competed in UEFA Champions League, UEFA Cup and Greek Cup.

Season started with Zdeněk Ščasný as team manager.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.