[3] Vitória by winning the Taça de Portugal, qualified for the 2005–06 UEFA Cup first round.
For the first round draw, teams were drawn against each other in accordance to their geographical location.
The draw was split up into four sections: teams from the north, the center, the south and the Azores region.
[9][10] The second round saw teams from the Portuguese Second Division (III) enter the competition.
The third round saw teams from the Liga de Honra (II) enter the competition.
The fourth round saw teams from the Primeira Liga (I) enter the competition.