The 2004–05 Winthrop Eagles men's basketball team represented Winthrop University in the 2004–05 NCAA Division I men's basketball season.

The Eagles, led by head coach Gregg Marshall, played their home games at the Winthrop Coliseum in Rock Hill, South Carolina, as members of the Big South Conference.

After losing their conference opener, the Eagles went on a 15-game win streak to run away with the Big South Conference regular season title.

They extended the streak to 18 games by winning the 2005 Big South tournament to earn the conference's automatic bid to the NCAA tournament.

14 seed in the Albuquerque region, Winthrop's streak came to an end as they were beaten by No.