Incumbent senator Joey Pendleton won reelection, defeating Republican Tracy Dean Hann.

Incumbent senator Richard L. "Dick" Roeding won reelection, defeating primary election challenger Charlie Walton.

Incumbent senator Vernie McGaha won reelection, defeating primary election challenger David Carr.

Incumbent senator Robert Stivers won reelection, defeating Constitution Party candidate Jeffrey L. Hillebrandt.

Incumbent senator Johnny Ray Turner won reelection, defeating primary election challenger Eric Shane Hamilton.

Incumbent senator Ray S. Jones II won reelection, defeating Republican candidate Chris Ratliff.

The winner of the general election, Republican candidate Dana Seum Stephenson, was later declared to be ineligible due to her failure to meet residency requirements outlined in the state constitution.

The seat remained vacant for over a year before a special election was held in February 2006, won by Democrat Perry B.