In the 2004 congressional elections, Daschle lost his seat to Republican challenger and former U.S. Representative John Thune in a bitterly contested battle.
Thune also used moral values such as issues surrounding same-sex marriage and abortion to convince South Dakota voters that Daschle's positions on such topics were out-of-sync with the state's residents.
The Republican candidate also drove home his strong support for the President while blasting Daschle for his vehement opposition to Bush.
His opponent, the Minority Leader, repeatedly argued that he was funneling money into South Dakota for vital federal highway and water pet projects.
Shortly following the airing of the ad, in a nationally televised debate on NBC's Meet the Press, Thune accused Daschle of "emboldening the enemy" in his skepticism of the Iraq War.
Some also argued that Stephanie Herseth's election to the state's only House seat hurt Daschle, as voters may not have been comfortable sending an all-Democratic delegation to Congress for the first time in many decades.
During the entire month of October into the November 2 election, most polls showed that Thune and Daschle were dead even, usually tied 49-49 among likely voters.